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In the STEP UP trial, it produced about 21% average weight loss, approaching the 22.5% weight loss seen with tirzepatide 15 mg injection in SURMOUNT-1
GLP-1 receptor agonist drugs like semaglutide and tirzepatide are highly effective for weight loss, but clinical trials show that 2540% of the weight lost can come from muscle, not just fat
Intracellularly, GSH is maintained in its thiol-reduced form by NADPH-dependent enzymes (glutathione disulfide bond (GSSG) reductase)
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