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Patients with pre-existing severe gastroparesis may experience worsening of their condition, which is why the FDA labeling includes cautions about use in patients with severe gastrointestinal disease
What that does not establish is any quantitative claim about how much the fasted-versus-fed difference matters for this blend at any modeled amount only that the direction of the effect is real and the timing logic is not arbitrary
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For those who do not receive enough B12 in their diet, or may not absorb B12 well, a B12 Injection is a safe and effective method to boost your B12 level