The 15 g dose is not lethal, the 18 g dose is marginally lethal, and the 30 g dose is definitely lethal without N-acetyl cysteine (NAC) rescue in the ER
Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults
The number 157 refers to the specific 15-amino-acid fragment within that parent protein
Traditional proteomics-based methods, such as N-terminomics 37,38,39 and proteomic identification of protease cleavage sites 40 , are well suited for global analyses of protease activity but can be low throughput and may lack the sensitivity to detect low-frequency, yet biologically perturbative, off-target cleavage events
Regular follow-up appointments will be scheduled to monitor your progress and adjust your treatment plan as needed
doi: 10.2174/1389557516666160609081602