These compounds work primarily on hepatic lipid metabolism and mitochondrial function
OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship
Because it is not clear that GLP-1 drugs are safe to take during pregnancy, women should stop these medications at least 2 months before trying to become pregnant or notify their doctor immediately if they become pregnant while taking these medications
The AI Because there was little information on the requirements of pantothenic acid in humans, the Food and Nutrition Board of the Institute of Medicine (now the National Academy of Medicine) set an adequate intake (AI) based on observed dietary intakes in healthy population groups ( Table 1 ) (22)
Both pair attractive valuations with strong management of ESG issues, positioning them well in the rapidly evolving obesity drug market
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