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DSIP is proposed to interact with components of the MAPK cascade via this mechanism providing a potential molecular basis for its glucocorticoid-related biology, anti-proliferative activity, and stress-protective effects
Deficiency may also result from poor absorption, which may increase as we age
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2013;4:e892
Early haematological response begins with reticulocytosis (increased production of immature red blood cells) typically by day 3-4 of treatment , particularly with injectable forms, though the full resolution of symptoms may take several weeks to months
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