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Grimes PE, Nashawati R
Among the E3 ligases, MuRF1 and Atrogin-1/MAFbx are canonical atrogenes strongly upregulated during catabolic stress (e.g., denervation, fasting, glucocorticoid exposure, cancer cachexia), and are indispensable for UPS-mediated muscle degradation
But, if either substances are pushed too quickly the resulting damage to the tissue can cause a nasty charley horse like pain that can persist for hours or days
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