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Anti-drug antibodies, which are strongly associated with injection site reactions, had no measurable effect on the pharmacokinetics, efficacy, or weight loss outcomes of tirzepatide treatment

Clinical observations describing reduced protein intake, variability in lean mass trajectories, and micronutrient insufficiency during pharmacologically induced weight loss [40, 75, 94, 95] suggest that long-term metabolic stability may become sensitive to substrate availability even in the absence of overt deficiency

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doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois

Its role within structured GLP-1 programs reflects a shift away from short-term interventions toward evidence-driven, medically guided metabolic support strategies

This requirement creates particular challenges in regions with unreliable electricity, hot climates, or limited access to medical-grade refrigeration