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This syndrome is characterized by clinical symptoms of sickness behavior such as leaden paralysis of the limbs, hypersomnia, and hyperphagia/weight gain, while mood reactivity is unimpaired, i.e., mood brightens in response to positive events (according to DSM-5 criteria for MDD with atypical features), while still suffering from lack of concentration and higher levels of exhaustibility as in melancholic MDD [99]
Using mice, the researchers investigated two areas in the brain stem, nucleus of the solitary tract (NST) and area postrema (AP), which are linked to feelings of satiety and vomiting responses, respectively
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Sacre JW, Magliano DJ, Shaw JE
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