The choice between tirzepatide and alternative agents should be guided by NICE recommendations (NG28 and relevant technology appraisals), considering factors such as HbA1c targets, cardiovascular risk profile, weight management goals, renal function, patient preferences, and the overall benefit-risk assessment
Exercise has been shown to exert beneficial effects on oxidative stress and inflammation, promoting overall health and potentially improving both spermatogenic and erectile functions (189)
Rapid injection is one of the primary causes of nodule formation and post-injection discomfort
For a 4 mg/mL pen concentration: 5 units = 0.25 mg 10 units = 0.5 mg 20 units = 1 mg Therefore, for a 4 mg/mL concentration, 40 units of semaglutide equal 2 mg

Adverse Reactions/Side Effects The following serious adverse reactions are described below or elsewhere in the prescribing information: Risk of Thyroid C-cell Tumors [see Warnings and Precautions (5.1)] Acute Pancreatitis [see Warnings and Precautions (5.2)] Diabetic Retinopathy Complications [see Warnings and Precautions (5.3)] Hypoglycemia with Concomitant Use of Insulin Secretagogues or Insulin [see Warnings and Precautions (5.4)] Acute Kidney Injury Due to Volume Depletion [see Warnings and Precautions (5.5)] Severe Gastrointestinal Adverse Reactions [see Warnings and Precautions (5.6)] Hypersensitivity Reactions [see Warnings and Precautions (5.7)] Acute Gallbladder Disease [see Warnings and Precautions (5.8)] Pulmonary Aspiration During General Anesthesia or Deep Sedation [see Warnings and Precautions (5.9)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice

Both use semaglutide and produce broadly similar weight loss