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Always follow your doctor's advice on when to take it

Starting weight also plays a significant role

Heusch G, Boengler K, Schulz R (2008) Cardioprotection: nitric oxide, protein kinases, and mitochondria

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In clinical trials for T2D, tirzepatide demonstrated superior reductions in HbA1c and body weight compared to other GLP-1 receptor agonists and insulin regimens