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Cyclic Heptapeptide Lactam-Bridged Macrocycle -MSH Analogue Reported Pharmacology (Literature, Neutral) Reported Melanocortin receptor agonism Non-selective MC1R / MC3R / MC4R / MC5R agonist Molinoff and colleagues (Ann N Y Acad Sci 2003) reported: PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Reported as a neutral pharmacology statement in the academic record

Keep in mind that the benefits also seem to go away after stopping treatment

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Curr Res Nutr Food Sci 2018;6(2)

Distribution of propensity scores

Proc Natl Acad Sci USA 1988