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[15] Severe or persistent pain in the anal region requires medical assessment, as it may indicate thrombosed external haemorrhoids or an anal fissure, both of which may require specific treatment

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PMCID: PMC12673431

When two agents both slow the stomach, the combined gastrointestinal effect and the accompanying nausea, early satiety, and, in some participants, vomiting can be additive, which is one reason CagriSema regimens use gradual dose escalation of both components

Other key factors of using Ozempic: Storage: Each Ozempic pen has four doses, and youll use the same pen to inject Ozempic once a week throughout the month

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