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4 Oxidative stress plays a central initiating role in the pathogenesis of vitiligo: the high metabolic activity of melanocytes leads to excessive generation of reactive oxygen species (ROS), while functional defects in the skins antioxidant system result in ROS accumulation, directly triggering mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis

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Taddio A, Manley J, Potash L, et al

White/pale patches on skin or mucous membranes, often on hands, face and feet Hair whitening premature greying of scalp, brows, lashes or beard in patches Spread pattern patches may stay localised or spread slowly and unpredictably Usually painless occasionally mild itching precedes a new patch

Each point represents a single mouse

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