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In a state of oxidative stress, the ratio can be as low as 10:1, and in severe states of oxidative stress, as low as 1:1

McCormack, J

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In the published Phase 1/2 trial, CJC-1295 with DAC showed no serious adverse events at doses up to 60 mcg/kg

Although some approved drugs such as metformin and propofol have been shown to induce ferroptosis, their primary therapeutic roles lie outside of ferroptosis induction, and the activation of other pathways by these drugs may lead to significant side effects

Supramolecular salicylic acid combined with niacinamide in chloasma: a randomized controlled trial