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doi: 10.1155/2020/8844280 108 GuillinO

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239 Phase II studies for type 2 diabetes did not achieve primary endpoints for glycemic control, showing only minor improvements in metabolic parameters

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The brain, sensing a drop in blood pressure and oxygen, initiates a "fight or flight" surge of adrenaline and norepinephrine, which causes the rapid, pounding heart rate (tachycardia), severe lightheadedness, and physical tremors associated with orthostatic intolerance