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Standard glutathione is often broken down by the digestive system before it can be absorbed

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As Frontiers in Endocrinology (2023) confirmed: "Most known selenoproteins, such as glutathione peroxidase, are expressed in the thyroid and are involved in thyroid hormone metabolism, redox state regulation, and maintenance of cellular homeostasis." In other words, selenium's documented benefits for Hashimoto's thyroiditis are mechanistically dependent on adequate glutathione availability

Understanding these causes is essential for appropriate clinical management and avoiding unnecessary alarm