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Never pack semaglutide in checked luggage where cargo hold temperatures can drop below freezing, and avoid placing it directly against ice packs, which can cause localized freezing
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Endocrinology 133:16851692 Yaekura K, Yada T (1998) [Ca 2+ ] i -reducing action of cAMP in rat pancreatic -cells: involvement of thapsigargin-sensitive stores
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2022;34(9):1234e12479
If you want a deeper look at why these digestive effects happen, our guide on why GLP-1 medications cause GI issues explains the mechanism in more detail
