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Baseline metabolic assessment can identify targetable phenotypes
These effects typically subside within a day
The production of quinone imine metabolite is the primary responsible for PAC liver and kidney toxicity
Kato N, Hasegawa U, Morimoto N, Saita Y, Nakashima K, Ezura Y, et al
Kaohsiung J Med Sci
In summary, metformin may affect EC through the modulation of glycolysis, lipogenesis, and protein synthesis, as well as inhibition of tumor cell growth and proliferation, and promotion of apoptosis
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