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ROS, also as a second messenger, can activate tyrosine kinases and MAPK which promote cell development (81), and the protein kinase-B (Akt)/mTOR signaling pathway which promotes cell growth of gastric cancer (82)

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The study set out to analyse the dose-response relationship of semaglutide in T2D and obesity, testing doses up to eight times higher than the currently approved maximum

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It also flags that, in a real-world environment, a meaningful share of patients may not tolerate the full dose