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Probably due to the binding preference of APAP to the active site of each P450 isomer, it is oxidized via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)

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There is an urgent need for investment in long Covid clinical trials, and in decentralized clinical trials like this one in particular, says Hannah Davis, cofounder of the Patient-Led Research Collaborative, a long Covid research and advocacy group

That balance looks different for everyone

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