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The side chains of all residues in the binding site are reminiscent of the 1EEM structure
This review examines the impact of obesity on the underlying mechanisms of HFpEF, summarizes the trial data on cardiovascular outcomes of GLP-1 RAs in patients with type 2 diabetes mellitus, and highlights the potential cardioprotective mechanisms of GLP-1 RAs to give a pathophysiological and clinical rationale for using GLP-1 RAs in obese HFpEF patients
Its low molecular weight (~340 Da) means it reaches tissue compartments that larger peptides may not, and its stability profile is well-suited to combination formulations
Experts say the exact amount of risk isn't known, though it's very low
Patients were randomized 1:1:1:1 to survodutide 2.4, 4.8, or 6 mg weekly, or placebo for 48 weeks
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