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SAM is regenerated again and again in a permanent cycle: it releases its methyl group in various reactions, and then goes through a series of reaction steps, through which it receives a new methyl group and is thus available again as a methyl donor

Each method has its own rules, like the vitamin B12 IV infusion dose

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In a clinical or home setting (with proper guidance), it is often injected in areas such as the upper arm, thigh, hip, or buttock

While direct delivery through injections enables maximum absorption and significant benefits for those with deficiencies, not everyone may experience the same outcomes with other advantages

However, it is not FDA-approved for medical treatment or injection, and regulatory status may vary by use