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In hair follicles, Wnt/beta-catenin activity is required for follicle formation during development and for anagen entry throughout adult life

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In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)

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These are predominantly present in the first eight to twelve weeks and resolve for the majority of participants after the body has adjusted to the compounds effects on gastric motility

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