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found that GLP-1RAs significantly increase the risk of gallstone disease in patients with T2DM [61]

Clinical Results with Combination Therapy The SURPASS-COMBO trial demonstrated remarkable outcomes with CagriSema

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Determination of the receptorligand co-crystal structures and mutational studies have led to a two-step model of peptide binding and receptor activation 17,18,19,20

Reassuring clinical data are starting to accrue: two multinational population-based cohort studies found no increased risk of major congenital malformations, live births, pregnancy losses, and pregnancy terminations during the periconceptional period with GLP-1 RAs [139]

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