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Objective methods for sleep disorders assessment in cirrhosis include the polysomnography test which stands as the gold standard for diagnosing sleep disturbances, but its practicality is hindered by high costs and patient compliance challenges

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FGF-21 inhibits NF-B signaling via the TLR4 receptor, protecting neurons from A-induced apoptosis and reducing neuroinflammation by downregulating NF-B, IL-6, and IL-8 [254]