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These data support the use of lower, better-tolerated doses of GLP-1RAs to treat HFpEF, potentially benefiting a wider range of patients, including those who are not obese or who suffer from side effects with current GLP-1 regimens

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The differences are the approved indications (diabetes mellitus vs weight loss) and route of administration (subcutaneous injection vs oral)

In fact, neurons of the lamina terminalis a key brain structure for sensing thirst and regulating water balance (20, 21) express GLP-1 receptors and are believed to confer satiety of thirst during fluid ingestion (22)

Patients often wonder whether increased skin laxity after fat loss will go away on its own, and the answer depends on several factors