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Current data shows tirzepatide produces slightly more total weight loss (20.9% vs 14.9-18.7%), but the trials used different durations

Ronis MJJ, Huang J, Crouch J, Mercado C, Irby D, Valentine CR, Lumpkin CL, Ingelman-sundberg M, Badger TM: Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentration in rats

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Foresta C, Ferlin A, Toni LD, Lana A, Vinanzi C, Galan A, et al