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75 In breast and ovarian cancers, for instance, hypomethylation of the ABCB1 (MDR1) promoter correlates with its overexpression, leading to elevated P-gp levels and enhanced efflux of chemotherapeutic agents, culminating in MDR

Liu et al., 2012

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For carriers of the effect allele at rs6265, these habits tend to produce a stronger measurable return because they directly reinforce the signaling environments where this variant has its greatest influence

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