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We would recommend trying weekly injections (if youre able to tolerate the side effects) for at least three full months before making a decision either way
Important safety considerations include common adverse effects such as gastrointestinal symptoms (nausea, vomiting, diarrhea), which occur in 20-40% of patients but typically diminish with continued use
The clinical efficacy is comparable: the OASIS 4 trial showed 13.6% weight loss with the oral 25 mg tablet versus 14.9% for the injection in STEP 1
Experimental evidence shows that dietary Trp supplementation improves motor deficits, enhances tyrosine hydroxylase expression, inhibits NF-B activation in the substantia nigra, and lowers circulating pro-inflammatory cytokines in toxin-induced, animal PD models [167]
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