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Constipation : Slowed digestion and bowel movements, with problems passing stool

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Gastrointestinal adverse events, including nausea, vomiting, diarrhea, constipation, and reduced oral intake, may limit dose escalation and lead to treatment interruption or discontinuation

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Collectively, these findings led Lonza to use exercise as a model to induce an inflammatory state and to upregulate ACE2 levels similar to those seen in chronic diseases