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One key process is glutamate excitotoxicity, where a buildup of glutamate at the synapse due to reduced function of the transporter EAAT2 (also known as GLT-1) leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors
From reducing the risk of heart attack to treating kidney disease
(2023): Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes
In addition, its high molecular weight (57 kDa) prevents renal clearance and prolongs its half-life (133)
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Surgical intervention may be necessary for complications such as bowel obstruction or fistulae
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