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Most people notice a change in appetite and weight within a few weeks to a few months

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J Neurosci 30(15):54375450 Ferrini F, De Koninck Y (2013) Microglia control neuronal network excitability via BDNF signalling

Indeed, VO2 peak is directly related to FFM, and normalizing to FFM reflects fitness related to exercise performance and cardiorespiratory function and has high prognostic value for mortality [33, 48,49,50]

Today, precision biologic therapies like Ranibizumab have changed that narrative, allowing many patients to retain functional vision and maintain their independence