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Further, changes in the indication space may have driven differences between periods, such as the increased prevalence of CHF observed in the later period

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Neurotrophin-3 , a growth factor produced by the body, may be able to combat age-related neurodegeneration in the gut, which could help relieve constipation

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A aggregation and tau hyperphosphorylation can disrupt the calcium balance in neurons, leading to mitochondrial calcium overload, increased reactive oxygen species production, reduced ATP generation, and ultimately, neuronal apoptosis or necrosis [76, 77]