Pharmacokinetic DDIs of GLP-1 RAs and a Dual GLP-1/GIP RA Drug-Metabolizing Enzyme-and Transporter-Mediated DDIs GLP-1 RAs and a dual GLP-1/GIP RA are now approved for the treatment of type 2 diabetes and obesity, with patients frequently managing coexisting metabolic diseases that require additional medications
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Lower treatment burden While retatrutide shows significant promise, Eli Lilly is likely to disrupt the market more imminently and more substantially following the launch of orforglipron in early 2026
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