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Indeed the activation of prodrugs in GST overexpressing cells may lead to high concentrations of an active drug, as compared to normal cells with moderate enzyme levels

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& El-Sayed, M

These included the phospholipid precursor PA(22:1(13Z)/19:2(10Z,13Z)), the free fatty acid Ricinoleic acid (5.1-fold), the oxidative stress marker 7-Oxo-11-dodecenoic acid, and monoacylglycerols, most notably MG(20:3(6,8,11)-OH(5)/0:0/0:0), which increased dramatically by 15.6-fold

What Is Bacteriostatic Water and How Is It Used