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Sin embargo, estos tratamientos no estn exentos de limitaciones: requieren inyecciones frecuentes, seguimiento mdico riguroso y almacenamiento en refrigeracin, y en muchos casos una preparacin previa a su administracin, como ayuno o titulacin progresiva de la dosis, es decir, el aumento gradual del medicamento a lo largo de varias semanas para mejorar su tolerancia y reducir efectos secundarios

Its not like its only delivered to the Eli Lilly plant or wherever a drug is being made

Thus, several microbiota-derived metabolites have been found to stimulate enteroendocrine L-cells producing GLP-1