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Jimnez, M

MC1R activation upregulates tyrosinase and other melanogenic enzymes, and new eumelanin accumulates in melanocytes over days

Anyone who is pregnant or planning a pregnancy should inform their clinician and trial team without delay

This mechanism contributes to glucose control through several physiological actions: Stimulating insulin release when blood glucose levels rise Reducing secretion of glucagon, a hormone that increases blood sugar Slowing gastric emptying, which helps control post-meal glucose spikes Promoting a feeling of fullness that may help reduce calorie intake Through these mechanisms, the medication helps patients achieve better metabolic balance and improved glycemic management

Start with gentle choices and build slowly

Injection-site reactions are a recognised consideration for subcutaneously administered agents of this class and will be further characterised in Phase 3 data