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In a controlled clinical setting (STEP 1 trial), participants with obesity who were prescribed semaglutide in combination with a structured lifestyle program lost an average of 14.9% of their body weight over 68 weeks
Yet despite their identical appearances, they were very different dosages
Cons: Can be more expensive than smaller programs
A midweek injection means you can adjust by a day or two in either direction without violating the 72-hour rule, giving you room to accommodate shifting travel schedules
However, it's always best to consult with a qualified professional to find the right approach for your needs
There is no pharmacological reason to choose one timing over the other, but stabilizing your GI baseline before adding new variables makes symptom attribution easier
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