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Therefore, a novel composite system integrating soluble microneedles with targeted nanoparticlestermed a nanoparticle-microneedle delivery platformholds significant potential for effective and sustained treatment of RA

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JAMA 305 , 16591668 (2011)

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Theoretical Risks and Safety Nuance Preclinical Safety Observations While no major adverse events are reported in the limited human data, researchers note theoretical concerns based on animal models