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And there are a few potential reasons why
The total impact score for each combination therapy was obtained by summing the individual pathway impact scores, calculated by the Disease Node Impact Score (as described in Section Estimating DM2 DMTs Drug Impact Effect Scores in the DM2-AD comorbidity network) for the pathways modulated by the respective drugs
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Pre-existing Conditions: Diabetes itself is a risk factor for UTIs, making it crucial to differentiate between the effects of the condition and the medication
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells
J Mol Endocrinol 25 , 141148 (2000)
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