Saltzman JR, Tabak YP, Hyett BH, et al
En biologie, lquilibre est fragile
Researchers comparing the best peptide for weight loss increasingly focus on retatrutide despite its higher cost, because the efficacy gap justifies the price premium
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For instance, another editorial, this one in the British Journal of Anesthesia (2024;132[5]:831-834), hypothesizes that the increase in myocardial injury after noncardiac surgery seen in patients with low preoperative N-terminal probrain natriuretic peptide (NT-proBNP) levels may be due to these patients having higher angiotensin II concentrations, leading to a more pronounced arterial rebound when treatment is withheld
This is echoed in a clinical practice discussion on addressing overweight and obesity, which reviews trial-level weight loss of around 1520% in major Phase 3 trials with current GLP-1 and dual-agonist agents and improvements in sleep apnea, fatty liver disease, and cardiovascular risk markers