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185 Estrogen taken orally undergoes transformation in the liver prior to reaching the systemic bloodstream, a phenomenon known as first pass. The by-products of estrogen metabolism in the liver have more negative side effects, particularly cardiovascular effects, than estrogen

However, because the liver uses some nutrients immediately, less may be available for the rest of the body, especially during times of stress, inflammation, high toxin exposure, or low nutrient intake, when the livers demand increases

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Vitamin B12 Benefits Boosts energy levels by supporting the conversion of protein and fat into energy, helping to combat fatigue

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