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Combination anti-TNF-alpha and thiopurine therapy increases the risk of serious opportunistic infections and hepatosplenic T-cell lymphoma
& Nishikawa, J.-I
10.3109/00365513.2012.734859 91 Vanessa LegryP
Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia
4) GPX4-independent ferroptosis suppressionDHODHCoQ10H 2 pathway in the mitochondria: Dihydroorotate dehydrogenase (DHODH), a flavin-dependent enzyme localized to the mitochondrial inner membrane, catalyzes the fourth step of pyrimidine biosynthesisconverting dihydroorotate (DHO) to orotate (OA)while transferring electrons to mitochondrial ubiquinone, reducing it to CoQ10H 2 , which acts as a radical-trapping antioxidant (107)
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