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Earth Sci
We showed that H89 or PKA siRNA blocked the protective effects of metformin on PA-induced endothelial dysfunction, suggesting that metformin alone might upregulate PKA signalling
It takes longer to reach therapeutic levels but can be the difference between someone who tolerates the medication long-term and someone who quits after two miserable weeks
doi: 10.1136/bmj.i4919 22
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