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This selectivity makes it appropriate for individuals seeking fat loss without broader hormonal changes or who have contraindications to growth hormone therapy such as insulin resistance or cancer history

G., Won, C

You're more likely to have vitamin B12 deficiency if you have a medical condition where your body can't absorb B12 or you follow a strict vegan diet

Metabolism 92 , 170192

In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]

Through its modulation of the NNMT-SAM-NAD+ axis, it enhances energy expenditure and supports more efficient utilization of fat stores for energy, making it a strong candidate in studies exploring metabolic optimization and obesity control