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In humans, dietary l-carnitine is converted into the atherosclerosis- and thrombosis-promoting metabolite TMAO via 2 sequential gut microbiotadependent transformations: (a) initial rapid generation of the atherogenic intermediate BB, followed by (b) transformation into TMA via low-abundance microbiota in omnivores, and to a markedly lower extent, in vegans/vegetarians

In our model we use a V max of 1100 M/hr, a K m of 3000 M, and a Hill coefficient of 3

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There is some data suggesting that acne may be exacerbated by GLP-1 agonists, while others believe that these medications may improve acne