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Concerning metabolism involvement, physiological examples are given by amino acids, in particular the alanines transport in the so-called glucosealanine cycle through the muscle tissue and liver

Chemical and physical properties of Exenatide Drug Target Endogenous incretins, including GLP-1 and GIP, facilitate glucose-dependent insulin secretion in response to food intake

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The upper left quadrant refers to the cholestasis range

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J Food Sci Technol 51:21552161 Marcolongo JP, Venncio MF, Rocha WR, Doctorovich F, Olabe JA (2019) NO/H 2 S Crosstalk reactions