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Incidence of acute coronary syndromes, cerebral infarction, acute peripheral arterial thrombosis, deep venous thrombosis, and overall arterial cardiovascular events at 5 years served as the primary outcome measures
However, owing to the lack of consideration for brain capillary binding or sequestration, the reliability of these results regarding brain uptake pharmacokinetics has been questioned [21] as well as whether results could be translated into humans
The short answer is yes, most GLP-1 medications require refrigeration before first use