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Cerebellar alpha-ketoglutarate dehydrogenase activity is reduced in spinocerebellar ataxia type 1

Because intramuscular B12 is absorbed more slowly over a longer time frame than intravenous delivery, each shot offers a sustained elevation in serum levels between appointments

These studies are the first to document the effectiveness of an oral nutritional supplement to directly affect NO synthesis

The Two Structural Modifications and Their Research Significance Analogues with substitutions, deletions, or insertions at the N-terminal end of native IGF-1 were found to reduce binding to IGFBPs and increase bioavailability to IGF-1R on cells a principle exploited in the design of LR3, where the arginine substitution and N-terminal extension together confer superior IGFBP evasion compared to shorter analogues such as Arg3 IGF-1, Gly3 IGF-1, and Des(1-3) IGF-1

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