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2.2.2 Pyroptosis Activation of the NLRP3 inflammasome is a critical trigger of pyroptosis, leading to gasdermin-mediated membrane pore formation and excessive release of pro-inflammatory cytokines such as IL-1 and IL-18
In this hypothesis, the homozygous thermolabile MTHFR mutation would predispose to folate deficiency, which is likely to increase the cardiovascular disease risk by elevating homocysteine levels
Clinical trial data can show what happened in a study population
Available at Kirzinger A, Lopes L, Muana C, et al
F., da Silva Duarte, V., Treu, L., Campanaro, S., Nadai, C., Giacomini, A., & Corich, V
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